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N,N-Dimethylglycine (short: DMG) is an intermediate of choline metabolism. Betaine (metabolized from choline and is a metabolic precursor to dimethylglycine) donates a methyl group to homocysteine to form methionine [1]. By this removal of one methyl group from betaine, dimethylglycine is formed [1]. DMG is often sold commercially as hydrochloride salt (dimethylglycine HCL).
Dimethylglycine’s Effects on Athletic Performance
Dimethylglycine has been claimed to be an athletic performance enhancer and can be found in various sports supplements. Since dimethylglycine donates methyl groups to transmethylation process it is claimed to improved energy usage. Therefore, it is often marketed and sold as an energiser.
File extension dmg. DMG files are files that are treated like actual hard disks by the Macintosh OS X operating system. These files can be created with Disk Copy, burned to a CD or even mounted as a normal volume on Macintosh computers. They often contain raw blocks of data that are usually compressed for easier file. Open DMG Files with DMG Extractor. DMG extractor provides another choice for extracting DMG files. The free version works well, but it does have some limitations: You cannot extract files bigger than 4 GB; You cannot extract encrypted files; You can only extract 5 files at a time, which can be a pain if you need to extract an entire DMG file. A file with the DMG file extension is an Apple Disk Image file, or sometimes called a Mac OS X Disk Image file, which is basically a digital reconstruction of a physical disc. For this reason, a DMG is often the file format used to store compressed software installers instead of having to use a physical disc. Mar 08, 2019 A DMG file is a mountable disk image created in macOS. It contains raw block data typically compressed and sometimes encrypted. DMG files are commonly used for macOS software installers that are downloaded from the Internet, which mount a virtual disk on the desktop when opened.
The interest in dimethylglycine arose from a report indicating that N,N-Dimethylglycine reduces lactic acid concentration in blood in response to surgical stress in animals [2]. Further human and animal studies yielded inconsistent results. A study on dimethylglycine-treated horses by Moffit et al. [3] reported lower plasma lactate concentrations after treadmill exercise. However, this study raised doubts about dimethylglycines effectiveness due to an unbalanced design used. Rose et al. [4] found no differences in muscle lactate concentrations in horses treated with dimethylglycine and horses receiving placebo.
In trained athletes, Pipes [5] noted a 23,6% increase in time to fatigue after DMG supplementation. In contrast, Gray and Larry [6] reported no significant changes in short-term maximal treadmill performance between the group receiving pangamic acid (calcium gluconate and N, N-Dimethylglycine) and control. No improvements in aerobic and anaerobic performance were also reported when 400 mg of DMG per/kg of body weight was administered to elite basketball players [7]. DMG also failed to improve maximal treadmill exercise to exhaustion in well-trained college women [8]. Authors of this study concluded that there is no evidence to recommend DMG as an ergogenic aid to endurance athletes.
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Dimethylglycine supplementation seems to have little to no effect on athletic performance besides evidence available is limited and conflicting. More well-researched clinical trials should be done before any definitive conclusions can be made. Mac cleanup pro activation key.
Other Dimethylglycine Uses
Treatment of Autism
N,N-dimethylglycine has also been reported to be beneficial in children with autism [9]. Kern et al. [9] reported that some children seem to respond positively to the dimethylglycine supplementation but overall behavioural assessments were not significantly different from children receiving placebo. Same was reported by Bolman and assistants [10], however, the weakness of this study is low dosage used in a small number of children. According to available evidence, subjects treated with DMG show little to no difference compared to untreated subjects for treatment of autism spectrum disorder [11].
Immunostimulant Properties
DMG may improve body’s immune system as reported by Graber and others [12]. Results of their study suggest that dimethylglycine supplementation improves humoral as well as cell-mediated immune responses in humans [12].
Side Effects
Very large doses up to 200 mg/kg given to animal models caused no adverse events [7]. This is not surprising as DMG is a natural metabolite which doesn’t build up in the body.
(Other common names: Pangamic Acid, Vitamin B15, Pangamate)
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References
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- Friesen, Russell W., et al. “Relationship of DMG, choline, and betaine with oxoproline in plasma of pregnant women and their newborn infants.” The Journal of nutrition 137.12 (2007): 2641-2646.
- Meduski, J. W., et al. 1980. “Decrease of lactic acid concentration in blood of animals given N,N-dimethylglycine.” Presented at Pacific Slope Biomedical Conference, Univ. of California, San Diego, (1980) 7-9.
- Moffitt, P., et al. “Venous lactic acid levels in exercising horses fed N, N-DMG.” Proceedings of the 9th Equine Nutrition and physiology Symposium, E., Lansing, Michigan. 1985.
- Rose, R. J., et al. “Effects of N, N-DMG on cardiorespiratory function and lactate production in thoroughbred horses performing incremental treadmill exercise.” Veterinary Record 125.10 (1989): 268-271.
- Pipes, T. V. “The effects of pangamic acid on performance in trained athletes.” Med. Sci. Sports Exercise (1980) 12:98
- Gray, Michael E., and Larry W. Titlow. “The effect of pangamic acid on maximal treadmill performance.” Medicine and science in sports and exercise 14.6 (1982): 424.
- Reza, Attarzadeh Seyed, et al. “The effect of DMG administration on Biochemical Blood Parameters in Youth elite Basketball Players.” (2013) 55-59.
- Brown, H., L. M. Reimnitz, and A. J. Koch. “No Effect of DMG on Maximal Aerobic Power.” The Journal of Strength & Conditioning Research 25 (2011): S109-S110.
- Kern, Janet K., et al. “Effectiveness of N, N-DMGin autism and pervasive developmental disorder.” Journal of Child Neurology 16.3 (2001): 169-173.
- Bolman, William M., and John A. Richmond. “A double-blind, placebo-controlled, crossover pilot trial of low dose DMGin patients with autistic disorder.” Journal of autism and developmental disorders 29.3 (1999): 191-194.
- Rossignol, Daniel A. “Novel and emerging treatments for autism spectrum disorders: a systematic review.” Ann Clin Psychiatry 21.4 (2009): 213-36.
- Graber, Charles D., et al. “Immunomodulating properties of DMGin humans.” Journal of Infectious Diseases 143.1 (1981): 101-105.